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Pentose phosphate pathway

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
D-glucono-1,5-lactone + H2O <=> H+ + D-gluconate 3.1.1.17 gluconolactonase
3.1.1.35 dihydrocoumarin hydrolase


D-arabino-hex-3-ulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.27 6-phospho-3-hexuloisomerase

ATP + beta-D-fructose_6-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.105 6-phosphofructo-2-kinase
2.7.1.11 6-phosphofructokinase


D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase

D-glyceraldehyde_3-phosphate + NAD+ + H2O <=> 3-phospho-D-glycerate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]






ATP + D-gluconate <=> H+ + 6-phosphogluconate + ADP 2.7.1.12 gluconokinase

2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




D-glyceraldehyde_3-phosphate + NADP+ + H2O <=> H+ + 3-phospho-D-glycerate + NADPH 1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]



6-phosphogluconate + NADP+ <=> 6-phospho-2-dehydro-D-gluconate + NADPH + H+ 1.1.1.43 phosphogluconate 2-dehydrogenase

alpha-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase

6-phospho-D-glucosaminate <=> 2-keto-3-deoxy_phosphogluconate + NH3 4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase

D-glucose + NAD+ <=> D-glucono-1,5-lactone + NADH + H+ 1.1.1.118 glucose 1-dehydrogenase (NAD+)
1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]





2-keto-3-deoxy_phosphogluconate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




D-gluconate + NADP+ <=> 2-dehydro-D-gluconate + NADPH + H+ 1.1.1.215 gluconate 2-dehydrogenase
1.1.1.346 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
1.1.1.43 phosphogluconate 2-dehydrogenase



alpha-D-ribose_1-phosphate <=> ribose_1,5-bisphosphate not assigned

6-phosphogluconate + NAD+ <=> 6-phospho-2-dehydro-D-gluconate + NADH + H+ 1.1.1.43 phosphogluconate 2-dehydrogenase

alpha-D-ribose_1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose_1-diphosphate + ADP 2.7.4.23 ribose 1,5-bisphosphate phosphokinase

D-glyceraldehyde + H2O + NADP+ <=> D-glycerate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)






sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> beta-D-fructose_6-phosphate + D-erythrose_4-phosphate 2.2.1.1 transketolase
2.2.1.2 transaldolase


ubiquinone + D-glucose <=> ubiquinol + D-glucono-1,5-lactone 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)
1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)


6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)



D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase


D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase

6-phosphogluconate <=> 2-keto-3-deoxy_phosphogluconate + H2O 4.2.1.12 phosphogluconate dehydratase

beta-D-fructose_6-phosphate + diphosphate <=> H+ + phosphate + D-fructose_1,6-bisphosphate 2.7.1.90 diphosphate---fructose-6-phosphate 1-phosphotransferase

2-deoxy-alpha-D-ribose_1-phosphate <=> 2-deoxy-D-ribose_5-phosphate 5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.7 phosphopentomutase
5.4.2.8 phosphomannomutase



D-gluconate <=> H2O + 2-dehydro-3-deoxy-D-gluconate 4.2.1.140 gluconate/galactonate dehydratase
4.2.1.39 gluconate dehydratase
4.2.1.82 xylonate dehydratase
4.2.1.9 dihydroxy-acid dehydratase




D-glucose + NADP+ <=> D-glucono-1,5-lactone + NADPH + H+ 1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.360 glucose/galactose 1-dehydrogenase
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase







O2 + D-glucose <=> D-glucono-1,5-lactone + H2O2 1.1.3.29 N-acylhexosamine oxidase
1.1.3.4 glucose oxidase
1.1.3.5 hexose oxidase



beta-D-glucose_6-phosphate + NADP+ <=> 6-phospho-D-glucono-1,5-lactone + NADPH 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)



D-glucose + a_quinone <=> D-glucono-1,5-lactone + a_quinol 1.1.3.4 glucose oxidase
1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)


2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose_5-phosphate + ADP + H+ 2.7.1.15 ribokinase
2.7.1.229 deoxyribokinase


2-deoxy-D-ribose_5-phosphate <=> D-glyceraldehyde_3-phosphate + acetaldehyde 4.1.2.4 deoxyribose-phosphate aldolase

6-phosphogluconate + NADP+ <=> D-ribulose_5-phosphate + CO2 + NADPH 1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)


sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> D-ribose_5-phosphate + D-xylulose_5-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase


D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


D-ribose + ATP <=> D-ribose_5-phosphate + ADP + H+ 2.7.1.15 ribokinase

D-glyceraldehyde + H2O + oxidized_ferredoxin <=> D-glycerate + H+ + reduced_ferredoxin 1.2.7.5 aldehyde ferredoxin oxidoreductase

D-glucose + NADP+ <=> D-glucono-1,5-lactone + NADPH + H+ 1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.360 glucose/galactose 1-dehydrogenase
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase







beta-D-fructose_6-phosphate + ADP <=> H+ + D-fructose_1,6-bisphosphate + AMP 2.7.1.146 ADP-specific phosphofructokinase

D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase




D-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.1 ribulose-phosphate 3-epimerase
5.3.1.34 D-erythrulose 4-phosphate isomerase


phosphate + D-xylulose_5-phosphate <=> H2O + D-glyceraldehyde_3-phosphate + acetyl_phosphate 4.1.2.22 fructose-6-phosphate phosphoketolase
4.1.2.9 phosphoketolase


D-gluconate + FAD + H+ <=> 2-dehydro-D-gluconate + FADH2 1.1.99.3 gluconate 2-dehydrogenase (acceptor)

6-phospho-D-glucono-1,5-lactone + H2O <=> H+ + 6-phosphogluconate 3.1.1.31 6-phosphogluconolactonase

D-arabino-hex-3-ulose_6-phosphate <=> D-ribulose_5-phosphate + formaldehyde 4.1.2.43 3-hexulose-6-phosphate synthase

D-ribose_5-phosphate + ATP <=> H+ + 5-phospho-alpha-D-ribose_1-diphosphate + AMP 2.7.6.1 ribose-phosphate diphosphokinase

2-dehydro-3-deoxy-D-gluconate + ATP <=> H+ + 2-keto-3-deoxy_phosphogluconate + ADP 2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase
2.7.1.45 2-dehydro-3-deoxygluconokinase


2-dehydro-D-gluconate + ATP <=> H+ + 6-phospho-2-dehydro-D-gluconate + ADP 2.7.1.13 dehydrogluconokinase
2.7.1.45 2-dehydro-3-deoxygluconokinase


D-glyceraldehyde + acceptor + H2O <=> D-glycerate + reduced_acceptor + H+ 1.2.99.8 glyceraldehyde dehydrogenase (FAD-containing)

D-glucosaminate + protein_Npi-phospho-L-histidine <=> 6-phospho-D-glucosaminate + protein_L-histidine 2.7.1.203 protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase

beta-D-glucose_6-phosphate + NAD+ <=> 6-phospho-D-glucono-1,5-lactone + NADH + H+ 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)


D-glucosaminate <=> 2-dehydro-3-deoxy-D-gluconate + NH3 4.3.1.9 glucosaminate ammonia-lyase

alpha-D-glucose_6-phosphate <=> beta-D-glucose_6-phosphate 5.1.3.15 glucose-6-phosphate 1-epimerase
5.1.3.3 aldose 1-epimerase
5.3.1.9 glucose-6-phosphate isomerase



alpha-D-ribose_1-phosphate <=> D-ribose_5-phosphate 5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.7 phosphopentomutase


Visualization of the pathway